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High incidence of symptomatic hyperammonemia in children with acute lymphoblastic leukemia receiving pegylated asparaginase

Use this break to: Assess baseline sleep quality without DSIP Allow any potential receptor adaptation to normalize Evaluate whether continued use is necessary or beneficial If returning to DSIP after the break, you may find your effective dose has changed

As such, and in response to these comments, we clarify that hospitals should report data from both prior to and after a contract negotiation date to capture a full 12-month period regardless of when the contract negotiation takes place