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(135) noted in their 2023 review that BCAA overload can activate the mTOR pathway while inhibiting the phosphatidylinositol 3-kinase (PI3K)-protein kinase B (Akt) intracellular pathway, leading to IR

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It is crucial to prevent the replacement or blockage of key interaction residues in the staple

If one considers that the Nrf2 transcription factor is transactivated following oxidative stress so as to stimulate autophagic flux (106,107), it is possible that taurine can attenuate the expression levels of Nrf2 transcription factor in the cerebrum of As2O3-exposed mice (103)