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The influence of HO-1 on the TME immunoprofile was highlighted by Alaluf et al., who reported that myeloid-specific ablation of HO-1 induced global transcriptional and epigenetic alterations not limited to the conventional M1/M2 polarization state of TAMs, but rather leading to extensive dysregulation of the central molecular signature of the TME (45)

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Colon sections were processed through the gut bundling technique, as previously described ( All samples were preserved at -80C until further utilization

In conclusion In summary, while L-carnosine and L-carnitine have some similarities in name, they are different compounds with different mechanisms of action and health benefits