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In the model proposed by Lee, homocysteine is shunted away from the methionine synthesis pathway and toward the GSH synthesis pathway, creating a relative deficiency of methyl donors in order to keep up with increased demand for the glutathione needed for POP conjugation ( Fig 3 )

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While effective for achieving pregnancy, letrozole targets the clinical consequence (anovulation) without rectifying the upstream metabolic or neuroendocrine dysregulation

Efficacy of non-surgical treatments for androgenetic alopecia: A systematic review and network meta-analysis