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Tryptophan metabolism bifurcates into both toxic (IS via tryptophanase) and protective (indole-3-propionic acid via alternative pathways) branches, with the latter enhancing intestinal barrier integrity through AhR-mediated tight junction upregulation (14, 111)

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doi: 10.1038/srep32619

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The biphasic dose-response The finding that 50 mg/mL outperformed 100 mg/mL mirrors what was observed in the laboratory copper peptides show optimal activity within a specific concentration window