In the MEL10 + ACR group, the levels of TNF-, IL-1, IL-6, NF-B, iNOS, COX-2, MPO, and p38 MAPK were reduced compared to the ACR group, but this reduction was not as effective as in the MEL20 + ACR group
Qiu A, Jansen M, Sakaris A, Min SH, Chattopadhyay S, Tsai E, et al
Biotransformation & Elimination The body treats xenobiotics as "foreign invaders and uses biotransformation, the metabolic process of converting compounds into more easily excretable forms, to detoxify and facilitate elimination
PMID: 32276632 This page provides educational information about SPCD treatment and crisis management
Kingdom Organic compounds Super Class Organic acids and derivatives Class Carboxylic acids and derivatives Sub Class Amino acids, peptides, and analogues Direct Parent Peptides Alternative Parents Tetracarboxylic acids and derivatives N-acyl-aliphatic-alpha amino acids L-alpha-amino acids D-alpha-amino acids Amino fatty acids Thioesters Sulfenyl compounds Propargyl-type 1,3-dipolar organic compounds Dialkylthioethers Carboxylic acids Carboximidic acids Monoalkylamines Hydrocarbon derivatives Carbonyl compounds Substituents Alpha peptide N-acyl-aliphatic-alpha amino acid Tetracarboxylic acid or derivatives N-acyl-alpha amino acid or derivatives N-acyl-alpha-amino acid L-alpha-amino acid D-alpha-amino acid Alpha-amino acid or derivatives Alpha-amino acid Amino fatty acid Fatty acyl Thiocarboxylic acid ester Dialkylthioether Organic 1,3-dipolar compound Propargyl-type 1,3-dipolar organic compound Sulfenyl compound Thioether Thiocarboxylic acid or derivatives Carboxylic acid Carboximidic acid derivative Carboximidic acid Hydrocarbon derivative Primary amine Organosulfur compound Organooxygen compound Organonitrogen compound Primary aliphatic amine Carbonyl group Amine Aliphatic acyclic compound Molecular Framework Aliphatic acyclic compounds External Descriptors Not Available Physical Properties State: Not Available Charge: -1 Melting point: Not Available Experimental Properties: Property Value Source Predicted Properties Property Value Source Water Solubility 0.0954 mg/mL ALOGPS logP -3.2 ALOGPS logP -2.2 ChemAxon logS -3.8 ALOGPS pKa (Strongest Acidic) 2.99 ChemAxon Physiological Charge -1 ChemAxon Hydrogen Acceptor Count 19 ChemAxon Hydrogen Donor Count 10 ChemAxon Polar Surface Area 348.67 2 ChemAxon Rotatable Bond Count 23 ChemAxon Refractivity 148.02 m 3 mol -1 ChemAxon Polarizability 63.02 3 ChemAxon Number of Rings 0 ChemAxon Bioavailability 0 ChemAxon Rule of Five Yes ChemAxon Ghose Filter Yes ChemAxon Veber's Rule Yes ChemAxon MDDR-like Rule Yes ChemAxon Biological Properties Cellular Locations: Cytoplasm Reactions: 2-(S-Glutathionyl)acetyl chloride + Glutathione 2-(S-Glutathionyl)acetyl glutathione + Hydrochloric acid Pathways: Not Available Spectra Spectra: Spectrum Type Description Splash Key Predicted LC-MS/MS Predicted LC-MS/MS Spectrum - 10V, Positive splash10-00di-3021198000-2833c46038b4903dcaeb View in MoNA Predicted LC-MS/MS Predicted LC-MS/MS Spectrum - 20V, Positive splash10-00di-9001261000-4d633b582f60af37eb94 View in MoNA Predicted LC-MS/MS Predicted LC-MS/MS Spectrum - 40V, Positive splash10-00di-9120120000-1ac1bb8421c5210b9029 View in MoNA Predicted LC-MS/MS Predicted LC-MS/MS Spectrum - 10V, Negative splash10-0a4r-0029017000-f8fad5a86ade04ae6a38 View in MoNA Predicted LC-MS/MS Predicted LC-MS/MS Spectrum - 20V, Negative splash10-0a4r-0269002000-0a762d4000e13c7792d1 View in MoNA Predicted LC-MS/MS Predicted LC-MS/MS Spectrum - 40V, Negative splash10-0005-3944010000-e5675376f58fb375ab75 View in MoNA References References: Kanehisa, M., Goto, S., Sato, Y., Furumichi, M., Tanabe, M
Gourdier I, Crabbe L, Andreau K, Pau B, Kroemer G
