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Enzymatically catalyzed molecular aggregation

Qiao and colleagues demonstrated that elevated serum TMAO significantly upregulated mRNA expression of pro-inflammatory M1 microglial markers (CD16, CD32, and iNOS) in the TMAO + MPTP experimental model, suggesting a potential mechanism by which high TMAO levels intensify neuroinflammatory processes in PD through M1 microglial polarization (Qiao et al., 2023)

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Greenhill LL, Swanson JM, Steinhoff K, Fried J, Posner K, Lerner M et al (2003)

Comparative transcriptome combined with morpho-physiological analyses revealed key factors for differential cadmium accumulation in two contrasting sweet sorghum genotypes