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However, the generalizability of the model is limited by data heterogeneity (such as cancer-specific bias), and the black box characteristics need to be combined with explainable AI (XAI) methods (such as SHAP values) to analyze mechanism associations ( 6.3 Global research progress Notable recent global research advances include the biomarker exploration of the GEMSTONE trial and the NCI-MATCH sub-program announced by ESMO in 2023 provides new directions for overcoming drug resistance: The GEMSTONE trial evaluated a novel oral gemcitabine formulation (such as liposomes or prodrug forms) (Zhang et al., 2024), which improved bioavailability by optimizing the drug delivery system (Zhang et al., 2024) and bypassed the hENT1 dependent cellular uptake pathway (Xi et al., 2020)

Several population-specific factors can impact glutathione's effectiveness, including dosage, route of administration, consistency, and reproducibility

In adults, glioblastoma is the most lethal tumor of the central nervous system