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In a chronic social defeat stress model in mice, 21 days of oral administration at 0.1 mg/kg corrected depressive-like behavior, restored motor activity with a therapeutic effect of 60 percent, completely recovered anhedonia, restored synaptophysin levels (74 percent therapeutic effect), and fully restored CREB levels in the hippocampus

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doi: 10.3390/ijms25179302 167 Committee on Carcinogenicity of Chemicals in Food, Consumer Products and the Environment (COC)

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PubMed record Cerovecki T, et al

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In previous work, Tsais lab has shown that transgenic mice engineered to express P25 develop severe neurodegeneration

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