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Although some genes involved in the platelet pathway were upregulated after PPE, they were not altered by necroptosis deficiency, indicating that AAA protection might be primarily mediated through reduced SMC necroptosis and inflammation

The redox status of the cell has a large effect on disulfide bond formation, protein folding, and dimerization of multidrug resistance (MDR) proteins such as MDR-1 (Liu et al., 2016), thereby increasing drug resistance (Tivnan et al., 2015)

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Anticancer Res 37:1591

Notably, serine synthesis enzymes (PHGDH, PSAT1, PSPH) were significantly higher in LUSC than in LUAD (Fig

In conclusion, though the drugs mentioned above showed good efficacy in preclinical or clinical trials, many tests and a long time would be required to apply to clinical treatment