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Metformin is distributed rapidly into various tissues, particularly the liver and gastrointestinal tract, and is excreted unchanged in the urine via active tubular secretion

13. Xie Z et al

These contact sites regulate calcium signaling, lipid synthesis, and protein folding

In the subgroup analysis by exercise frequency, exercising less than three times per week did not significantly affect the increase in SOD activity (SMD = 0.08