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116,117 It is a homo-dimeric transmembrane protein whose extracellular domain can connect with the other same molecules of neighboring endothelial cells in the paracellular cleft, and the cytoplasmic domain can interact with the actin filaments via scaffolding proteins

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30 Diagnosis Clinicians must rely on clinical experience, interpretation of symptoms, and evaluation of medical history in order to tentatively diagnose a patient as having Parkinson's disease

doi: 10.1016/j.biomaterials.2021.121103 174 DaiYShanWYangQGuoJZhaiRTangXet al

Neuroprotective therapies will need to target multiple pathological pathways such as mitochondrial dysfunction and neuroinflammation in the next few years

This section covers what is known about safety along with theoretical concerns