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You dont want to cover the needs of only half the population though, so you add two relative standard deviations to cover more like 98% of the population, which just means you up the average requirement by 20 or 40%

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Petznek H, Kleiter M, Tichy A, Fuchs-Baumgartinger A, Hohenadl C (2014): Murine xenograft model demonstrates significant radio-sensitising effect of liposomal doxorubicin in a combination therapy for Feline Injection Site Sarcoma

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