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Molecular Structure Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg Molecular Formula: CHNOS Molecular Weight: 2174.64 g/mol PubChem SID: 255386757 CAS Number: 1627580-64-6 Synonyms: Mitochondrial Open Reading Frame of the 12S rRNA-C, MT-RNR1 Source: PubChem Key Actions Research has identified several key physiological effects of MOTS-c: Activates AMPK , increasing glucose uptake and metabolic flexibility Promotes fat oxidation and reduces lipid accumulation Enhances mitochondrial function and ATP energy production Improves insulin sensitivity in skeletal muscle Increases exercise performance and endurance Reduces inflammation and regulates cytokine signaling Supports neuroprotection and cognitive function Preserves lean muscle mass and combats sarcopenia Mitigates oxidative stress and improves redox balance May contribute to longevity by maintaining mitochondrial homeostasis MOTS-c: Key Research Areas and Potential Benefits 1

[28] Metal ion binding [edit] Beyond the iron-sulfur proteins, many other metal cofactors in enzymes are bound to the thiolate substituent of cysteinyl residues

doi: 10.1539/joh.N8001

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