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Vaccination with rEE2 and rMCP antigens induces memory recall responses The first vaccinated elephant (A) received 20% of the eventual viral dose of MVA and half of the g protein boost dose during the first rMVA-EE2-MCP prime and protein boost cycle to initially assess safety and determine the dose range, which was then increased in the second prime-boost cycle to the final dose used in the rest of the trial

According to Soutar et al

[DOI] [PMC free article] [PubMed] [Google Scholar] 39.Zhang L., Lu S

The capsaicin pretreatment was also effective in the reversal of esophagoprotection induced by melatonin and such capsaicin deactivation of sensory nerves by capsaicin significantly reduced plasma NOx suggesting that sensory nerves contribute to the esophageal protection mainly by stimulation of NO generation possibly via releasing sensory neuropeptide such calcitonin gene-related peptide (CGRP) that is known to stimulate the activity of NOS and release of NO, protecting the mucosal lining of GIT (45)

Danysz W, Parsons CG

243 YaoH.FanR.ZhaoX.ZhaoW.LiuW.YangJ.et al (2016)