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Herrmann M, Obeid R, Scharhag J, Kindermann W, Herrmann W

However, the group receiving both AOD9604 and HA showed the most favorable results, suggesting a potential synergistic interaction

J Chem Technol Biotechnol 91:585595

however, since both receptors share a high degree of structural and functional homology, the IGF1R can bind insulin and the IR can bind the IGFs with reduced affinity