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Because the Kras G12D -Myc axis has been suggested to induce Nrf2 gene expression and increased the activity of Nrf2 in pancreatic cancers ( Another unique regulator of the pentose phosphate pathway is the tumor suppressor p53, which inhibits the pentose phosphate pathway through binding to G6PD and preventing the formation of the active dimer (Jiang et al., 2011)

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Increased efflux of oxidized glutathione (GSSG) causes glutathione depletion and potentially diminishes antioxidant defense in sickle erythrocytes

[DOI] [PMC free article] [PubMed] [Google Scholar] 146.Chen WJ, et al