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If you are experiencing night sweats and one or more of the following symptoms, you should contact a healthcare provider: Unexplained weight loss Fever Chills New or worsening symptoms such as cough, fatigue, or pain Night sweats that wake you from sleep, or that last for two weeks or more Sweating that drenches your sheets If you are a woman close to 50 and start having night sweats, it could be an indicator of menopause, though you should see a doctor to confirm the diagnosis