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A significantly decreases GSH levels in MC65 nerve cells, increases nonenzymatic and enzymatic oxidation of arachidonic acid (COX, 5-LOX, 12-LOX, and 15-LOX), and increases mitochondrial ROS levels and total intracellular lipid peroxides

( A ) Uniform manifold approximation and projection (UMAP) plot showing clustering of intestinal epithelial cell types isolated from the crypts of WT mice and analyzed by single-cell RNA sequencing

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At age 20, plasma concentrations average approximately 200 ng/mL