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Ask patients to report pregnancies to their physicians as soon as possible [see Warnings and Precautions (5.1), Use in Specific Populations (8.1)]

At follow-up, confirm ongoing indication for DOAC use, review current medications for drug-drug interactions, assess patients relative risks of bleeding and/or thromboembolism, and address any adverse events

Prophylactic pegfilgrastim to prevent febrile neutropenia among patients receiving biweekly (Q2W) chemotherapy regimens: a systematic review of efficacy, effectiveness and safety