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Toll-like receptor 5 (TLR5), the PRR which recognizes flagellin on the epithelial surface, is also involved in the maintenance of gut microbiota homeostasis

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We and others previously showed that rodent -cells do not synthesize significant L-DOPA or DA de novo, but produce ample quantities of DA in response to uptake of exogenous L-DOPA 6,7,9

Among participants with prediabetes at baseline, 87.7% achieved normoglycemia, highlighting the potential of this combination therapy to modify the natural history of dysglycemia