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Here, we summarized the role of the vicious cycle of mitochondrial damage and ROS accumulation in RA and introduced potential drugs that target mitochondria or scavenge ROS for RA treatment, with the aim of providing some help for the clinical treatment of RA ( Table 1 )

Describe the role of NADPH in detoxifying reactive oxygen species, and explain which cell types depend the most on the pentose phosphate pathway

Additionally, we employed a genetic knockout of Caspase Recruitment Domain-9 (CARD9), which impairs the immune response against fungi

Cibulskis, K

[124], these decreases are frequently accompanied by increased levels of malondialdehyde (MDA) and total oxidant status (TOS), which indicate continued oxidative intake of antioxidants

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