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Furthermore, DOX upregulates the expression of key mitochondrial enzymes, including DLAT [78]

Applying several hours before bed is fine but slightly suboptimal

Front Pharmacol 14:1218015

Current theories concerning disease pathogenesis include an imbalance between protease and anti-protease activity, induced apoptosis of alveolar cells through deregulation of pathways involved in oxidative stress, chronic inflammation, and aberrant tissue remodeling that lead to the destruction of the extracellular matrix (ECM) in the lung [3, 4]