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Mechanism of Action How Dihexa activates the HGF/c-Met pathway to promote synaptogenesis, dendritic spine formation, and long-term potentiation

Oral collagen peptides: 10 to 15 grams daily to provide raw materials for connective tissue repair

Separate-vials Reconstitution Reference Compound Cagrilintide Vial size 5 mg BAC water 2.0 mL Concentration 2.5 mg/mL Weekly draw at 2.4 mg 0.96 mL = 96 units U-100 Compound Cagrilintide Vial size 10 mg BAC water 3.0 mL Concentration 3.33 mg/mL Weekly draw at 2.4 mg 0.72 mL = 72 units U-100 Compound Semaglutide Vial size 5 mg BAC water 2.0 mL Concentration 2.5 mg/mL Weekly draw at 2.4 mg 0.96 mL = 96 units U-100 Compound Semaglutide Vial size 10 mg BAC water 3.0 mL Concentration 3.33 mg/mL Weekly draw at 2.4 mg 0.72 mL = 72 units U-100 Volumes near 1 mL exceed standard U-100 / 0.3 mL syringe capacity

Lack of specific preclinical disease models The in vitro BBB models, as well as disease models that exist today, are poorly predictive tools

See, Carfrae et al

There are three tyrosine kinase inhibitors (TKIs) which target MET that are currently approved for use as monotherapy in the treatment of cancers - crizotinib (PF-02341066), cabozantinib (XL-184) and capmatinib (INC280)