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Journal of Physiology-Paris , 93 (6), 479485

Abbreviations Ach: Acetylcholine AChE: Acetylcholinesterase AD: Alzheimers disease ANOVA: Analysis of variance BChE: Butyrylcholinesterase CA: Catalase ChAT: Choline acetyltransferase CPCSEA: Committee for the Purpose of Control and Supervision of Experiments on Animals DTNB: 5,5-Dithio-bis-(2-nitrobenzoic acid) EDTA: Ethylenediaminetetraacetic acid FDA: Food and Drug Administration IAEC: Institutional Animal Ethics Committee LPO: Lipid peroxidation MWM: Morris water maze NO: Nitric oxide level NBT: Nitroblue tetrazolium SOD: Superoxide dismutase activity TSH: Tissue homogenates TSTQ: Time spent in target quadrant References Zhang J, Shi L, Shen Y

Problemi strutturali principali: assenza di randomizzazione, campioni ridotti, mancanza di replica da gruppi indipendenti

Two severe adverse events were reported: viral meningitis (in cagrilintide 1.2 mg + semaglutide 2.4 mg) and an increase in serum creatinine (in placebo + semaglutide 2.4 mg), but both events were deemed unrelated to study treatment by the study investigator