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Since caffeine is structurally similar to adenosine, it competitively antagonizes the effects of adenosine by binding to some of the same receptors

(Kind of a big deal!) And if you have a deficiency, taking B12 pills or getting a B12 shot are both legit ways to up those B12 levels

The potential for gastrointestinal adverse effects, particularly nausea and vomiting, may lead to dehydration and worsening of renal function in vulnerable patients

It reacts in patients with rare hereditary galactose or fructose intolerance

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Footnotes Contributors: TAS, IK, MH and RKC conceived the study, and contributed to study design, sample size calculations and analytical plans