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Description

Effect of VX-770 in persons with cystic fibrosis and the G551D-CFTR mutation

Levels decline significantly with age

J Appl Microbiol 94(3):449455

Busler J, Grant L, Liao V, Lin A, Rahman S, Mahon P

The immune cells in these patients are dealing with such an extreme, unrelenting burden of oxidative stress and mitochondrial lipid damage that they have frantically ramped up their own internal glutathione production in a desperate attempt to survive