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Description

Deletion of both Gpx4 alleles in mice or pharmacologic GPX4 inhibition in cells induces a distinct regulated form of iron-dependent cell death termed ferroptosis 1

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and 4 ) double-strand break repair (DSBR), to intervene when both strands of the DNA backbone break (whereas the breakage of only 1 strand is handled by the BER pathway) (57)

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