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This review comprehensively summarizes the potential mechanisms by which vagus nerve stimulation (VNS) intervenes in PD may influence the microbiota-gut-brain axis (MGBA), including the regulation of gut microbiota composition and metabolites, inhibition of central and peripheral neuroinflammatory responses, modulation of hypothalamicpituitaryadrenal (HPA) axis function, enhancement of brain region functional connectivity and neurotrophic factor secretion, and explores its potential value in translating into clinical therapeutic strategies

However, mitochondrial dysfunction involves many inducible factors, among which specific and effective targets are required for further clinical use

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[Google Scholar] [50].Mattiasson B (ed.), Expanded Bed Chromatography, 1st ed, Springer, Netherlands, 1999

( IGF1 gene was found in multiple tissues throughout embryonic and post-natal development (Roberts et al., 1987