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A major obstacle to acquisition of metal cofactors by apoenzymes is that the binding sites for these cofactors frequently lack the capacity to discriminate between different divalent metal cations and cofactors (

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This HIV-1 induced MP metabolism is accompanied by extracellular accumulation of -KG and Gln (see also Tables 1, 2) (Barrero et al., 2013

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(A) Cytosolic and mitochondrial ROS level was measured using the H2DCFDA and MitoSOX red fluorescence probe method respectively as described in materials and methods