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Description

Combining a high dose of oral PL7737 with dual GIPR/GLP-1R agonist tirzepatide caused DIO rats to lose 15% of their body weight compared to vehicle control after four days of treatment, an additive effect compared to either treatment alone (138)

Regarding clinical endpoints, meta-analyses showed reductions in the incidence of all-cause mortality, ventricular arrhythmia, and anginal episodes

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