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10.1039/C9NR08747H 79 HuangT.HeJ

These modifications have been hypothesized to play a crucial role in the diffusion of DNA damage response/senescence-associated secretory phenotype (DDR/SAPS) signaling to non-damaged surrounding cells during aging, suggesting that DDR/SASP signaling components may contribute to the development of novel therapeutic interventions against age-related diseases (Olivieri et al., 2015)

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Still, you can function almost normally, though usually with the help of stimulants like coffee

In the nucleus, NRF2 binds to antioxidant response elements (ARE) in the promoter regions of its target genes, leading to the transcription of genes that mitigate oxidative damage, support cellular redox balance, and enhance survival mechanisms (Lou et al., 2021)