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When introduced into living organisms, such as mouse model, siRNA/Ap-CS nanostructures can reach specific tissues and organs by the blood circulation system and enter into target cancer cells by aptamerreceptor interaction without the need of transfection reagents (step IV)

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Ascorbate increases human oxaluria and kidney stone risk

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This process can involve gut microbiota metabolites crossing the blood-brain barrier, modulating the microbiota-gut-brain axis, and regulating microglial activity and cytokine release