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Consistently, in clinical studies, loss of EZH2, upregulation of KDM6 and reduced H3K27 Me3 are associated with multiple drug resistance and poor prognosis of AML patients (Gollner et al., 2017

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Gupta R, Mehan S, Sethi P, Prajapati A, Alshammari A, Alharbi M, Al-Mazroua HA, Narula AS (2022) Smo-Shh agonist purmorphamine prevents neurobehavioral and neurochemical defects in 8-OH-DPAT-induced experimental model of obsessive-compulsive disorder