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Since -hydroxybutyrylation competes with acetylation on p53, an increase in -HB due to calorie restriction or a ketogenic diet would reduce p53 acetylation, affecting p53 activity 80

Okazaki K, Chari ST, Frulloni L, et al

Older and more engaged: The mediating role of age-linked resources on work engagement

Thus, modes of administration of the composition of the present disclosure (either alone or in combination with other pharmaceuticals) can be, but are not limited to, sublingual, injectable (including short-acting, depot, implant and pellet forms injected subcutaneously or intramuscularly), or by use of vaginal creams, suppositories, pessaries, vaginal rings, rectal suppositories, intrauterine devices, and transdermal forms such as patches and creams

(PubMed) Thapliyal R, Maru GB

A comprehensive review of free radicals, oxidative stress, and antioxidants: Overview, clinical applications, global perspectives, future directions, and mechanisms of antioxidant activity of flavonoid compounds