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Additionally, nicotine exposed mice show upregulated expression of VCAM-1, COX-2, platelet-derived growth factor (PDGF), and molecules involved in downstream of NF-B signaling pathway in aorta lesions [279]

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Role of functional genetic variation in the dopamine D2 receptor (DRD2) in response to bupropion and nicotine replacement therapy for tobacco dependence: results of two randomized clinical trials