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And yet we still experience pain and sorrow

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Pediatrics 143(5):e20183531 Buchanan ND, Grimmer JA, Tanwar V, Schwieterman N, Mohler PJ, Wold LE (2020) Cardiovascular risk of electronic cigarettes: a review of preclinical and clinical studies

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It uses Freebase nicotine, with two nicotine levels to choose from: 3mg and 6mg, accommodating different preferences

The researchers also allowed for potential confounding factors (in addition to age and sex) such as body mass index, blood pressure and cholesterol levels, that may have skewed results