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Considering the fact that tumour microenvironment stresses are strong inducers of the endoplasmic reticulum stress (Murakami et al, 2007), the FASN inhibitors could show selective and enhanced cytotoxicity to cancer cells under the tumour microenvironment conditions

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The meningococcal genome has a glutamine synthetase but lacks a functional glutamate synthase and, therefore, a Glutamine Synthetase (GS)/Glutamine Oxoglutarate Aminotransferase (GOGAT) cycle, suggesting a major role for NADP-GDH in ammonia assimilation

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