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Tobacco Statistics & Facts ASH > Action on Smoking & Health Smoking is a major cause of cardiovascular disease, which is the single leading cause of death in the U.S. Smoking causes one of every five deaths from cardiovascular disease. Learn more about Tobacco Use Health, United States Smoking Facts and Statistics Strong Tobacco Control in US Averts 4M Deaths from Lung Cancer American Cancer Society Smoking is still the leading cause of preventable death in the U.S. Doctors may soon have new tools to help people quit AAMC

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