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In experimental CKD models, natural bioactive compounds with kidney protective potential are associated with NFE2L2 activation [103,104]

Key takeaways Acetaminophen interactions can increase the risk of liver damage, especially when combined with drugs that affect its metabolism or are toxic to the liver themselves

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To overcome this limitation, we performed a small molecule screen to identify HIF-2dependent vulnerabilities

KD is a high-fat, very low-carbohydrate, and moderate-protein dietary approach that induces ketosis, defined by serum ketone body concentrations exceeding 0.5 mmol/L