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Severe Hypokalemia: A Critical Drop in Potassium Levels One of the most serious complications of B12 replacement therapy in severe megaloblastic anemia (a type of anemia where blood cells are abnormally large) is the development of severe hypokalemia (dangerously low potassium levels in the blood)

It should also be noted that some key factors of the mechanism summarized in this review (such as DNMTs, G9a, TFs, etc.), especially internalization-related -arrestins, are also expressed in other cells besides neurons and participate in various normal physiological activities

doi: 10.1146/annurev.nutr.24.012003.132306