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They also noted that the major variable in the composition of the smoke was the terpene content, with a 40-fold difference between the lowest and the highest levels

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Some of the substances are classified as hard narcotics, like heroin, but the use of these is very limited as they are usually not commercially available

[83] Nicotine addiction is a disorder which alters different neural systems such as dopaminergic, glutamatergic, GABAergic, serotoninergic, that take part in reacting to nicotine

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