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Compared with traditional meta-analysis using linear mixed effect models, MR-BRT relaxes the assumption of a log(linear) relationship between exposure and risk, incorporates between-study heterogeneity into the uncertainty of risk estimates, handles estimates reported across different exposure categories, automatically identifies and trims outliers, and systematically tests and adjusts for bias due to study designs and characteristics

still smoke ( Active tobacco use in patients with PAD is strongly associated with a higher risk of disease progression, worse post-procedural outcomes, early failure of revascularization therapies, increased hospitalizations, and cardiovascular events including myocardial infarction and death ( 3

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He has also been inducted into the Rock and Roll Hall of Fame