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These authors, including a Nobel-Prize winning researcher, also warn, substance use disorders do not develop from a single drug encounter but require repeated exposures that result in enduring epigenetic and synaptic changes. This research team studied the effects of a cannabinoid on cocaine cross-sensitization only, not on the development of cocaine use disorders

Prevention is widely recognized as the most effective approach in addressing smoking and its associated health risks, including respiratory problems, cardiovascular diseases, and various types of cancer, says Wonha Kim, MD, MPH, assistant professor of pediatrics and preventative medicine and director of Loma Linda University Health Institute for Health Policy and Leadership

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An off-target KRAS -mutation (p.Q61K) occurred in association with subsequent progression under second-line TKI treatment