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First, the self-medication hypothesis proposes that individuals with SZ choose to smoke to alleviate the clinical symptoms and cognitive deficits that are characteristic of the illness as well as the side effects of antipsychotic medications (41)

It's the most common failure point and, thankfully, the easiest to check

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Alexander Nemerov, Frederic Remington and Turn-of-the-Century America (New Haven: Yale University Press, 1995), 5, 19

The constant choice of simplicity and quality helps tobacco farmers both in the mechanization and in reducing maintenance times