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At present, endothelial cell dysfunction is the earliest detectable change in the development of an atherosclerotic lesion, which may contribute to a series of CVDs including vascular inflammation, hypertension and cardiomyopathy [105]

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24 found that the overexpression of TERT in transgenic mice can improve the adaptability of the epithelial barrier, especially skin and intestinal tract, and lead to the delay of body aging, accompanied by the extension of the median life span, indicating that TERT has anti-aging activity in the mammalian body

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