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Results showed that epithelial activation (EGFR expression), clefts/fragmentation in the Rbm, and EMT biomarkers (S100A4 and MMP-9) were significantly regressed after treatment in the ICS group compared to the placebo group [152]

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In the varenicline group, one participant experienced moderate postoperative haemorrhage considered unrelated to the study drug and one experienced two serious adverse events of a loss of consciousness and a resultant traffic incident

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