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Both solvents and flavoring agents may generate toxic byproducts, such as formaldehyde, a substance classified as a probable human carcinogen, the review authors wrote

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By continuously rolling out new marketing campaigns and innovating their products to avoid oversight, the tobacco industry is intent on recruiting new tobacco users and continuing to threaten public health. A long history of industry targeting The study is the result of exhaustive research of tobacco industry marketing and internal corporate correspondence since the 1930s, including company advertisements targeting specific consumer segments by skin color, gender and age over the course of decades