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The industrial method passed the hand-rolled type in numbers in the mid-1980s and today kretek dominates up to 90% of the Indonesian cigarette market

A large body of evidence showed that direct skin exposure to cigarette smoke containing a large number of oxidants and radical species 40 leads to lipid peroxidation 41 associated with the skin barrier impairment demonstrated by the increased TEWL in various experimental models 5, 6 as well as in the cheek of smokers 4

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