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Early Dutch reports on the region spoke to centuries-old agricultural traditions present in many of the local native tribes

women smokers were associated with prostitution and smoking was not considered an activity fit for proper ladies

Integrative analyses showed associations between microbial composition and host gene expression, such as CD74 positively correlated with Lactobacillus and PPP1R3C negatively with Bacteroidota, suggesting that smoking-induced microbial shifted might interact with host transcriptional programs to promote OSCC progression [59]

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